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Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

Histone deacetylase 3 (Hdac3) is an enzymatic component of transcriptional repression complexes recruited by the nuclear hormone receptors. Inactivation of Hdac3 in cancer cell lines triggered apoptosis, and removal of Hdac3 in the germ line of mice caused embryonic lethality. Therefore, we deleted...

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Main Authors: Knutson, Sarah K, Chyla, Brenda J, Amann, Joseph M, Bhaskara, Srividya, Huppert, Stacey S, Hiebert, Scott W
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323257/
https://ncbi.nlm.nih.gov/pubmed/18354499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.51
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