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Fast-folding protein kinetics, hidden intermediates, and the sequential stabilization model

Do two-state proteins fold by pathways or funnels? Native-state hydrogen exchange experiments show discrete nonnative structures in equilibrium with the native state. These could be called hidden intermediates (HI) because their populations are small at equilibrium, and they are not detected in kine...

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Détails bibliographiques
Auteurs principaux: Ozkan, S. Banu, Dill, Ken A., Bahar, Ivet
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2002
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373683/
https://ncbi.nlm.nih.gov/pubmed/12142450
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