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The role of disulfide bond in the amyloidogenic state of β(2)-microglobulin studied by heteronuclear NMR
β(2)-Microglobulin (β2-m) is a major component of dialysis-related amyloid fibrils. Although recombinant β2-m forms needle-like fibrils by in vitro extension reaction at pH 2.5, reduced β2-m, in which the intrachain disulfide bond is reduced, cannot form typical fibrils. Instead, thinner and flexibl...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373597/ https://ncbi.nlm.nih.gov/pubmed/12192077 |
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