The role of disulfide bond in the amyloidogenic state of β(2)-microglobulin studied by heteronuclear NMR

β(2)-Microglobulin (β2-m) is a major component of dialysis-related amyloid fibrils. Although recombinant β2-m forms needle-like fibrils by in vitro extension reaction at pH 2.5, reduced β2-m, in which the intrachain disulfide bond is reduced, cannot form typical fibrils. Instead, thinner and flexibl...

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Bibliografiset tiedot
Päätekijät: Katou, Hidenori, Kanno, Takashi, Hoshino, Masaru, Hagihara, Yoshihisa, Tanaka, Hiroyuki, Kawai, Tomoji, Hasegawa, Kazuhiro, Naiki, Hironobu, Goto, Yuji
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2002
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373597/
https://ncbi.nlm.nih.gov/pubmed/12192077
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