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NMR-based characterization of a refolding intermediate of β2-microglobulin labeled using a wheat germ cell-free system

In patients with dialysis-related amyloidosis, β2-microglobulin (β2-m) is a major structural component of amyloid fibrils. It has been suggested that the partial unfolding of β2-m is a prerequisite to the formation of amyloid fibrils, and that the folding intermediate trapped by the non-native trans...

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Detalhes bibliográficos
Main Authors: Kameda, Atsushi, Morita, Eugene-Hayato, Sakurai, Kazumasa, Naiki, Hironobu, Goto, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776947/
https://ncbi.nlm.nih.gov/pubmed/19606503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.179
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