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Increase in the conformational flexibility of β(2)-microglobulin upon copper binding: A possible role for copper in dialysis-related amyloidosis
A key pathological event in dialysis-related amyloidosis is the fibril formation of β(2)-microglobulin (β2-m). Because β2-m does not form fibrils in vitro, except under acidic conditions, predisposing factors that may drive fibril formation at physiological pH have been the focus of much attention....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2286743/ https://ncbi.nlm.nih.gov/pubmed/14767076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03445704 |
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