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Increase in the conformational flexibility of β(2)-microglobulin upon copper binding: A possible role for copper in dialysis-related amyloidosis

A key pathological event in dialysis-related amyloidosis is the fibril formation of β(2)-microglobulin (β2-m). Because β2-m does not form fibrils in vitro, except under acidic conditions, predisposing factors that may drive fibril formation at physiological pH have been the focus of much attention....

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Villanueva, James, Hoshino, Masaru, Katou, Hidenori, Kardos, József, Hasegawa, Kazuhiro, Naiki, Hironobu, Goto, Yuji
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Cold Spring Harbor Laboratory Press 2004
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286743/
https://ncbi.nlm.nih.gov/pubmed/14767076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03445704
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