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Increase in the conformational flexibility of β(2)-microglobulin upon copper binding: A possible role for copper in dialysis-related amyloidosis

A key pathological event in dialysis-related amyloidosis is the fibril formation of β(2)-microglobulin (β2-m). Because β2-m does not form fibrils in vitro, except under acidic conditions, predisposing factors that may drive fibril formation at physiological pH have been the focus of much attention....

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Bibliografske podrobnosti
Main Authors: Villanueva, James, Hoshino, Masaru, Katou, Hidenori, Kardos, József, Hasegawa, Kazuhiro, Naiki, Hironobu, Goto, Yuji
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286743/
https://ncbi.nlm.nih.gov/pubmed/14767076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03445704
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