β-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic β cells

Glucagon-like peptide-1 (GLP-1) is a polypeptide hormone secreted from enteroendocrine L cells and potentiates glucose-dependent insulin secretion in pancreatic β cells. Recently the GLP-1 receptor (GLP-1 R) has been a focus for new anti-diabetic therapy with the introduction of GLP-1 analogues and...

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Bibliographic Details
Main Authors: Sonoda, Noriyuki, Imamura, Takeshi, Yoshizaki, Takeshi, Babendure, Jennie L., Lu, Juu-Chin, Olefsky, Jerrold M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373360/
https://ncbi.nlm.nih.gov/pubmed/18445652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710402105
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