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β-Arrestin-1 Competitively Inhibits Insulin-Induced Ubiquitination and Degradation of Insulin Receptor Substrate 1

β-Arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between receptor tyrosine kinases and GPCR signaling. In the present study, we determined...

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Bibliografske podrobnosti
Main Authors: Usui, Isao, Imamura, Takeshi, Huang, Jie, Satoh, Hiroaki, Shenoy, Sudha K., Lefkowitz, Robert J., Hupfeld, Christopher J., Olefsky, Jerrold M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC517874/
https://ncbi.nlm.nih.gov/pubmed/15456867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.20.8929-8937.2004
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