β-Arrestin-1 Competitively Inhibits Insulin-Induced Ubiquitination and Degradation of Insulin Receptor Substrate 1

β-Arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between receptor tyrosine kinases and GPCR signaling. In the present study, we determined...

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Pubblicato in:Mol Cell Biol
Autori principali: Usui, Isao, Imamura, Takeshi, Huang, Jie, Satoh, Hiroaki, Shenoy, Sudha K., Lefkowitz, Robert J., Hupfeld, Christopher J., Olefsky, Jerrold M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2004
Soggetti:
Cell Growth and Development
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC517874/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15456867/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.20.8929-8937.2004
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