β-Arrestin-1 Competitively Inhibits Insulin-Induced Ubiquitination and Degradation of Insulin Receptor Substrate 1

β-Arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between receptor tyrosine kinases and GPCR signaling. In the present study, we determined...

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Detalhes bibliográficos
Main Authors: Usui, Isao, Imamura, Takeshi, Huang, Jie, Satoh, Hiroaki, Shenoy, Sudha K., Lefkowitz, Robert J., Hupfeld, Christopher J., Olefsky, Jerrold M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517874/
https://ncbi.nlm.nih.gov/pubmed/15456867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.20.8929-8937.2004
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