Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats

We investigated the chronic in vivo effect of resistin on insulin sensitivity and glucose metabolism by overexpressing resistin protein in male Wistar rats using intravenous administration of an adenovirus encoding mouse resistin. After 7 days of elevated resistin levels at a supraphysiological conc...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Satoh, Hiroaki, Nguyen, M.T. Audrey, Miles, Philip D.G., Imamura, Takeshi, Usui, Isao, Olefsky, Jerrold M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449745/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15254589/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20785
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