Insulin Induces Heterologous Desensitization of G Protein-Coupled Receptor and Insulin-Like Growth Factor I Signaling by Downregulating β-Arrestin-1

β-Arrestin-1 mediates agonist-dependent desensitization and internalization of G protein-coupled receptors (GPCRs) and is also essential for GPCR mitogenic signaling. In addition, insulin-like growth factor I receptor (IGF-IR) endocytosis is facilitated by β-arrestin-1, and internalization is necess...

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Detalhes bibliográficos
Main Authors: Dalle, Stéphane, Imamura, Takeshi, Rose, David W., Sears Worrall, Dorothy, Ugi, Satoshi, Hupfeld, Christopher J., Olefsky, Jerrold M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134007/
https://ncbi.nlm.nih.gov/pubmed/12167719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.17.6272-6285.2002
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