Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes

Protein phosphatase 2A (PP2A) is a multimeric serine/threonine phosphatase which has multiple functions, including inhibition of the mitogen-activated protein (MAP) kinase pathway. Simian virus 40 small t antigen specifically inhibits PP2A function by binding to the PP2A regulatory subunit, interfer...

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Bibliografiske detaljer
Main Authors: Ugi, Satoshi, Imamura, Takeshi, Maegawa, Hiroshi, Egawa, Katsuya, Yoshizaki, Takeshi, Shi, Kun, Obata, Toshiyuki, Ebina, Yousuke, Kashiwagi, Atsunori, Olefsky, Jerrold M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC516764/
https://ncbi.nlm.nih.gov/pubmed/15367694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.19.8778-8789.2004
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