Insulin Induces Heterologous Desensitization of G Protein-Coupled Receptor and Insulin-Like Growth Factor I Signaling by Downregulating β-Arrestin-1

β-Arrestin-1 mediates agonist-dependent desensitization and internalization of G protein-coupled receptors (GPCRs) and is also essential for GPCR mitogenic signaling. In addition, insulin-like growth factor I receptor (IGF-IR) endocytosis is facilitated by β-arrestin-1, and internalization is necess...

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Bibliografiska uppgifter
Huvudupphovsmän: Dalle, Stéphane, Imamura, Takeshi, Rose, David W., Sears Worrall, Dorothy, Ugi, Satoshi, Hupfeld, Christopher J., Olefsky, Jerrold M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2002
Ämnen:
Cell Growth and Development
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC134007/
https://ncbi.nlm.nih.gov/pubmed/12167719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.17.6272-6285.2002
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