Single-molecule observations of topotecan-mediated TopIB activity at a unique DNA sequence

The rate of DNA supercoil removal by human topoisomerase IB (TopIB) is slowed down by the presence of the camptothecin class of antitumor drugs. By preventing religation, these drugs also prolong the lifetime of the covalent TopIB–DNA complex. Here, we use magnetic tweezers to measure the rate of su...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Koster, Daniel A., Czerwinski, Fabian, Halby, Ludovic, Crut, Aurélien, Vekhoff, Pierre, Palle, Komaraiah, Arimondo, Paola B., Dekker, Nynke H.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2008
Предметы:
Nucleic Acid Enzymes
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367732/
https://ncbi.nlm.nih.gov/pubmed/18292117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn035
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы