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Dynamics of phosphodiester synthesis by DNA ligase

Ligases are essential actors in DNA replication, recombination, and repair by virtue of their ability to seal breaks in the phosphodiester backbone. Ligation proceeds through a nicked DNA-adenylate intermediate (AppDNA), which must be sealed quickly to avoid creating a potentially toxic lesion. Here...

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Autori principali: Crut, Aurélien, Nair, Pravin A., Koster, Daniel A., Shuman, Stewart, Dekker, Nynke H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2383972/
https://ncbi.nlm.nih.gov/pubmed/18458338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800113105
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