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Dynamics of phosphodiester synthesis by DNA ligase
Ligases are essential actors in DNA replication, recombination, and repair by virtue of their ability to seal breaks in the phosphodiester backbone. Ligation proceeds through a nicked DNA-adenylate intermediate (AppDNA), which must be sealed quickly to avoid creating a potentially toxic lesion. Here...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2383972/ https://ncbi.nlm.nih.gov/pubmed/18458338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800113105 |
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