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Cellular strategies for regulating DNA supercoiling: A single-molecule perspective
Excess entangling and twisting of cellular DNA (i.e., DNA supercoiling) are problems inherent to the helical structure of double-stranded DNA. Supercoiling affects transcription, DNA replication, and chromosomal segregation. Consequently the cell must fine-tune supercoiling to optimize these key pro...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997354/ https://ncbi.nlm.nih.gov/pubmed/20723754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.08.001 |
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