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Immunization by Avian H5 Influenza Hemagglutinin Mutants with Altered Receptor Binding Specificity
Influenza virus entry is mediated by the receptor binding domain (RBD) of its spike, the hemagglutinin (HA). Adaptation of avian viruses to humans is associated with HA specificity for α2,6- rather than α2,3-linked sialic acid (SA) receptors. Here, we define mutations in influenza A subtype H5N1 (av...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2367145/ https://ncbi.nlm.nih.gov/pubmed/17690300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1135165 |
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