Immunization by Avian H5 Influenza Hemagglutinin Mutants with Altered Receptor Binding Specificity

Influenza virus entry is mediated by the receptor binding domain (RBD) of its spike, the hemagglutinin (HA). Adaptation of avian viruses to humans is associated with HA specificity for α2,6- rather than α2,3-linked sialic acid (SA) receptors. Here, we define mutations in influenza A subtype H5N1 (av...

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Bibliografiset tiedot
Päätekijät: Yang, Zhi-Yong, Wei, Chih-Jen, Kong, Wing-Pui, Wu, Lan, Xu, Ling, Smith, David F., Nabel, Gary J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367145/
https://ncbi.nlm.nih.gov/pubmed/17690300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1135165
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