Inhibiting transthyretin conformational changes that lead to amyloid fibril formation
Insoluble protein fibrils resulting from the self-assembly of a conformational intermediate are implicated as the causative agent in several severe human amyloid diseases, including Alzheimer’s disease, familial amyloid polyneuropathy, and senile systemic amyloidosis. The latter two diseases are ass...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9789022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.22.12956 |
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