Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

Insoluble protein fibrils resulting from the self-assembly of a conformational intermediate are implicated as the causative agent in several severe human amyloid diseases, including Alzheimer’s disease, familial amyloid polyneuropathy, and senile systemic amyloidosis. The latter two diseases are ass...

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Bibliografiske detaljer
Main Authors: Peterson, Scott A., Klabunde, Thomas, Lashuel, Hilal A., Purkey, Hans, Sacchettini, James C., Kelly, Jeffrey W.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC23669/
https://ncbi.nlm.nih.gov/pubmed/9789022
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