Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

Insoluble protein fibrils resulting from the self-assembly of a conformational intermediate are implicated as the causative agent in several severe human amyloid diseases, including Alzheimer’s disease, familial amyloid polyneuropathy, and senile systemic amyloidosis. The latter two diseases are ass...

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Bibliografiska uppgifter
Huvudupphovsmän: Peterson, Scott A., Klabunde, Thomas, Lashuel, Hilal A., Purkey, Hans, Sacchettini, James C., Kelly, Jeffrey W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 1998
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC23669/
https://ncbi.nlm.nih.gov/pubmed/9789022
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