Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

Insoluble protein fibrils resulting from the self-assembly of a conformational intermediate are implicated as the causative agent in several severe human amyloid diseases, including Alzheimer’s disease, familial amyloid polyneuropathy, and senile systemic amyloidosis. The latter two diseases are ass...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Peterson, Scott A., Klabunde, Thomas, Lashuel, Hilal A., Purkey, Hans, Sacchettini, James C., Kelly, Jeffrey W.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1998
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9789022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.22.12956
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