Characterization of an immortalizing N-terminal domain of polyomavirus large T antigen.

Polyomavirus large T antigen has an N-terminal domain of approximately 260 amino acids which can immortalize primary cells but lacks sequences known to be required for DNA binding and replication. Treatment of full-length large T with either V8 protease or chymotrypsin yields an N-terminal fragment...

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Publicat a:J Virol
Autors principals: Holman, P S, Gjoerup, O V, Davin, T, Schaffhausen, B S
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236501/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8289370/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.2.668-673.1994
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