Human Enteric Microsomal CYP4F Enzymes O-Demethylate the Antiparasitic Prodrug Pafuramidine

CYP4F enzymes, including CYP4F2 and CYP4F3B, were recently shown to be the major enzymes catalyzing the initial oxidative O-demethylation of the antiparasitic prodrug pafuramidine (DB289) by human liver microsomes. As suggested by a low oral bioavailability, DB289 could undergo first-pass biotransfo...

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Hauptverfasser: Wang, Michael Zhuo, Wu, Judy Qiju, Bridges, Arlene S., Zeldin, Darryl C., Kornbluth, Sally, Tidwell, Richard R., Hall, James Edwin, Paine, Mary F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364724/
https://ncbi.nlm.nih.gov/pubmed/17709372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.107.016428
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