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CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]

DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime] is biotransformed to the potent antiparasitic diamidine DB75 [2,5-bis(4-amidinophenyl) furan] by sequential oxidative O-demethylation and reductive N-dehydroxylation reactions. Previous work demonstrated that the N-dehydroxylation reactions...

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Autors principals: Wang, Michael Zhuo, Saulter, Janelle Y., Usuki, Etsuko, Cheung, Yen-Ling, Hall, Michael, Bridges, Arlene S., Loewen, Greg, Parkinson, Oliver T., Stephens, Chad E., Allen, James L., Zeldin, Darryl C., Boykin, David W., Tidwell, Richard R., Parkinson, Andrew, Paine, Mary F., Hall, James Edwin
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077835/
https://ncbi.nlm.nih.gov/pubmed/16997912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.106.010587
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