Clinical pharmacokinetic and in vitro combination studies of nolatrexed dihydrochloride (AG337, Thymitaq(TM)) and paclitaxel

A clinical study of nolatrexed dihydrochloride (AG337, Thymitaq(TM)) in combination with paclitaxel was performed. The aims were to optimize the schedule of administration and determine any pharmacokinetic (PK) interactions between the two drugs. In vitro combination studies were performed to assist...

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Bibliografiske detaljer
Main Authors: Hughes, A N, Griffin, M J, Newell, D R, Calvert, A H, Johnston, A, Kerr, B, Lee, C, Liang, B, Boddy, A V
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2000
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363406/
https://ncbi.nlm.nih.gov/pubmed/10789718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1172
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