Clinical pharmacokinetic and in vitro combination studies of nolatrexed dihydrochloride (AG337, Thymitaq(TM)) and paclitaxel

A clinical study of nolatrexed dihydrochloride (AG337, Thymitaq(TM)) in combination with paclitaxel was performed. The aims were to optimize the schedule of administration and determine any pharmacokinetic (PK) interactions between the two drugs. In vitro combination studies were performed to assist...

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Detalhes bibliográficos
Main Authors: Hughes, A N, Griffin, M J, Newell, D R, Calvert, A H, Johnston, A, Kerr, B, Lee, C, Liang, B, Boddy, A V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363406/
https://ncbi.nlm.nih.gov/pubmed/10789718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1172
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