Cremophor EL causes (pseudo-) non-linear pharmacokinetics of paclitaxel in patients

The non-linear plasma pharmacokinetics of paclitaxel in patients has been well established, however, the exact underlying mechanism remains to be elucidated. We have previously shown that the non-linear plasma pharmacokinetics of paclitaxel in mice results from Cremophor EL. To investigate whether C...

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Main Authors: Tellingen, O van, Huizing, M T, Panday, V R Nannan, Schellens, J H M, Nooijen, W J, Beijnen, J H
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1999
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362856/
https://ncbi.nlm.nih.gov/pubmed/10496361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690696
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