Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic–pharmacodynamic study

AIMS: To assess quantitatively the safety and pharmacology of paclitaxel in patients with moderate to severe hepatic impairment. METHODS: Solid tumour patients were enrolled into five liver function cohorts as defined by liver transaminase and total bilirubin concentrations. Paclitaxel was administe...

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Detalhes bibliográficos
Main Authors: Joerger, M, Huitema, A D R, Huizing, M T, Willemse, P H B, de Graeff, A, Rosing, H, Schellens, J H M, Beijnen, J H, Vermorken, J B
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
Assuntos:
Pharmacokinetics and Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203269/
https://ncbi.nlm.nih.gov/pubmed/17935602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02956.x
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