Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function

AIMS: The aim of the study was to determine the effect of renal impairment and prior platinum-based chemotherapy on the toxicity and pharmacokinetics of oral topotecan and to identify recommended doses for patients with renal impairment or prior platinum-based (PB) chemotherapy. METHODS: A multicent...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Devriese, Lot A, Witteveen, Petronella (Els) O, Mergui-Roelvink, Marja, Smith, Deborah A, Lewis, Lionel D, Mendelson, David S, Bang, Yung-Jue, Chung, Hyun Choel, Dar, Mohammed M, Huitema, Alwin D R, Beijnen, Jos H, Voest, Emile E, Schellens, Jan H M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541973/
https://ncbi.nlm.nih.gov/pubmed/25677219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12606
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