Phase I and pharmacological study of pazopanib in combination with oral topotecan in patients with advanced solid tumours

BACKGROUND: This phase I study evaluated the safety, tolerability, maximum tolerated dose (MTD) and pharmacokinetics of two dosing schedules of oral topotecan in combination with pazopanib in patients with advanced solid tumours. METHODS: Stage I of this study was to determine whether there was an i...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Kerklaan, B Milojkovic, Lolkema, M P J, Devriese, L A, Voest, E E, Nol-Boekel, A, Mergui-Roelvink, M, Langenberg, M, Mykulowycz, K, Stoebenau, J, Lane, S, Legenne, P, Wissel, P, Smith, D A, Giantonio, B J, Schellens, J H M, Witteveen, P O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559826/
https://ncbi.nlm.nih.gov/pubmed/26291057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.257
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