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The amino-terminal region of Tyk2 sustains the level of interferon α receptor 1, a component of the interferon α/β receptor

Tyk2 belongs to the Janus kinase (JAK) family of receptor associated tyrosine kinases, characterized by a large N-terminal region, a kinase-like domain and a tyrosine kinase domain. It was previously shown that Tyk2 contributes to interferon-α (IFN-α) signaling not only catalytically, but also as an...

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Autors principals: Gauzzi, M. Cristina, Barbieri, Giovanna, Richter, Marc F., Uzé, Gilles, Ling, Leona, Fellous, Marc, Pellegrini, Sandra
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC23625/
https://ncbi.nlm.nih.gov/pubmed/9342324
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