A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-α signaling

Tyrosine kinases of the Janus kinase family initiate cellular responses through their association with receptors for α-helical cytokines. In addition to a tyrosine kinase domain, these enzymes possess a kinase-like (KL) domain, whose function remains elusive. To investigate the role of the KL domain...

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Hlavní autoři: Yeh, Tammie C., Dondi, Elisabetta, Uzé, Gilles, Pellegrini, Sandra
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2000
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC16809/
https://ncbi.nlm.nih.gov/pubmed/10908660
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