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A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-α signaling
Tyrosine kinases of the Janus kinase family initiate cellular responses through their association with receptors for α-helical cytokines. In addition to a tyrosine kinase domain, these enzymes possess a kinase-like (KL) domain, whose function remains elusive. To investigate the role of the KL domain...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2000
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC16809/ https://ncbi.nlm.nih.gov/pubmed/10908660 |
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