Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2

Type I IFNs are critical players in host innate and adaptive immunity. IFN signaling is tightly controlled to ensure appropriate immune responses as imbalance could result in uncontrolled inflammation or inadequate responses to infection. It is therefore important to understand how type I IFN signal...

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Autores principales: Piganis, Rebecca A. R., De Weerd, Nicole A., Gould, Jodee A., Schindler, Christian W., Mansell, Ashley, Nicholson, Sandra E., Hertzog, Paul J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190811/
https://ncbi.nlm.nih.gov/pubmed/21757742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.270207
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