Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2

Type I IFNs are critical players in host innate and adaptive immunity. IFN signaling is tightly controlled to ensure appropriate immune responses as imbalance could result in uncontrolled inflammation or inadequate responses to infection. It is therefore important to understand how type I IFN signal...

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Hlavní autoři: Piganis, Rebecca A. R., De Weerd, Nicole A., Gould, Jodee A., Schindler, Christian W., Mansell, Ashley, Nicholson, Sandra E., Hertzog, Paul J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190811/
https://ncbi.nlm.nih.gov/pubmed/21757742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.270207
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