A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans

Type I interferons (IFN), best known for their anti-viral functions, have been shown to impair host resistance to intracellular bacteria in mice. However, the precise role of type I IFN signaling in bacterial infection in humans is unclear. Here, we show that genetic variation in the human IFNAR1 ge...

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Publicado no:Nat Commun
Main Authors: Zhang, Guoliang, deWeerd, Nicole A., Stifter, Sebastian A., Liu, Lei, Zhou, Boping, Wang, Wenfei, Zhou, Yiping, Ying, Binwu, Hu, Xuejiao, Matthews, Antony Y., Ellis, Magda, Triccas, James A., Hertzog, Paul J., Britton, Warwick J., Chen, Xinchun, Feng, Carl G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758831/
https://ncbi.nlm.nih.gov/pubmed/29311663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02611-z
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