Palmitoylation of Interferon-α (IFN-α) Receptor Subunit IFNAR1 Is Required for the Activation of Stat1 and Stat2 by IFN-α

Type I interferons (IFNs) bind IFNAR receptors and activate Jak kinases and Stat transcription factors to stimulate the transcription of genes downstream from IFN-stimulated response elements. In this study, we analyze the role of protein palmitoylation, a reversible post-translational lipid modific...

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Bibliographic Details
Main Authors: Claudinon, Julie, Gonnord, Pauline, Beslard, Emilie, Marchetti, Marta, Mitchell, Keith, Boularan, Cédric, Johannes, Ludger, Eid, Pierre, Lamaze, Christophe
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782026/
https://ncbi.nlm.nih.gov/pubmed/19561067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.021915
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