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The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression
The four mammalian Jak tyrosine kinases are non-covalently associated with cell surface receptors binding helical bundled cytokines. In the type I interferon receptor, Tyk2 associates with the IFNAR1 receptor subunit and positively influences ligand binding to the receptor complex. Here, we report t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140723/ https://ncbi.nlm.nih.gov/pubmed/12554654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg038 |
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