Tyk2 Tyrosine Kinase Expression Is Required for the Maintenance of Mitochondrial Respiration in Primary Pro-B Lymphocytes

Tyk2, a member of the Jak family of protein tyrosine kinases, is critical for the biological actions of alpha/beta interferon (IFN-α/β). Although Tyk2(−/−) mice are phenotypically normal, they exhibit abnormal responses to inflammatory challenges in a variety of cells isolated from Tyk2(−/−) mice. T...

Full description

Saved in:
Bibliographic Details
Main Authors: Potla, Ramesh, Koeck, Thomas, Wegrzyn, Joanna, Cherukuri, Srujana, Shimoda, Kazuya, Baker, Darren P., Wolfman, Janice, Planchon, Sarah M., Esposito, Christine, Hoit, Brian, Dulak, Jozef, Wolfman, Alan, Stuehr, Dennis, Larner, Andrew C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636766/
https://ncbi.nlm.nih.gov/pubmed/16982690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00497-06
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items