Basal Ubiquitin-independent Internalization of Interferon α Receptor Is Prevented by Tyk2-mediated Masking of a Linear Endocytic Motif

Linear endocytic motifs of signaling receptors as well as their ubiquitination determine the rate of ligand-induced endocytosis that mediates down-regulation of these receptors and restricts the magnitude and duration of their respective signal transduction pathways. We previously hypothesized that,...

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Detalhes bibliográficos
Main Authors: Kumar, K. G. Suresh, Varghese, Bentley, Banerjee, Anamika, Baker, Darren P., Constantinescu, Stefan N., Pellegrini, Sandra, Fuchs, Serge Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441555/
https://ncbi.nlm.nih.gov/pubmed/18474601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800991200
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