Restoration of p16(INK4A) protein induces myogenic differentiation in RD rhabdomyosarcoma cells

p16(INK4A) (p16) tumour suppressor induces growth arrest by inhibiting function of cyclin-dependent kinase (CDK)4 and CDK6. Homozygous p16 gene deletion is frequent in primary rhabdomyosarcoma (RMS) cells as well as derived cell lines. To confirm the significance of p16 gene deletion in tumour biolo...

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Bibliografske podrobnosti
Main Authors: Urashima, M, Teoh, G, Akiyama, M, Yuza, Y, Anderson, K C, Maekawa, K
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1999
Teme:
Regular Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362237/
https://ncbi.nlm.nih.gov/pubmed/10098732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690165
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