Restoration of p16(INK4A) protein induces myogenic differentiation in RD rhabdomyosarcoma cells

p16(INK4A) (p16) tumour suppressor induces growth arrest by inhibiting function of cyclin-dependent kinase (CDK)4 and CDK6. Homozygous p16 gene deletion is frequent in primary rhabdomyosarcoma (RMS) cells as well as derived cell lines. To confirm the significance of p16 gene deletion in tumour biolo...

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Bibliographic Details
Main Authors: Urashima, M, Teoh, G, Akiyama, M, Yuza, Y, Anderson, K C, Maekawa, K
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1999
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362237/
https://ncbi.nlm.nih.gov/pubmed/10098732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690165
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