AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell

The chimeric PAX3-FKHR transcription factor is present in a majority of alveolar rhabdomyosarcoma (ARMS), an aggressive skeletal muscle cancer of childhood. PAX3-FKHR-mediated aberrant myogenic gene expression resulting in escape from terminal differentiation program is believed to contribute in ARM...

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Hlavní autoři: Jothi, Mathivanan, Nishijo, Kochi, Keller, Charles, Mal, Asoke K
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
Témata:
Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323795/
https://ncbi.nlm.nih.gov/pubmed/22333587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.5.19346
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