Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles

Acquired drug resistance is a major problem in cancer treatment. To explore the genes involved in chemosensitivity and resistance, 10 human tumour cell lines, including parental cells and resistant subtypes selected for resistance against doxorubicin, melphalan, teniposide and vincristine, were prof...

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Main Authors: Rickardson, L, Fryknäs, M, Dhar, S, Lövborg, H, Gullbo, J, Rydåker, M, Nygren, P, Gustafsson, M G, Larsson, R, Isaksson, A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2005
Fag:
Genetics and Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361589/
https://ncbi.nlm.nih.gov/pubmed/16012520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602699
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