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Structure-activity relationship analysis of cytotoxic cyanoguanidines: selection of CHS 828 as candidate drug

BACKGROUND: N-(6-(4-chlorophenoxy)hexyl)-N'-cyano-N''-4-pyridyl guanidine) (CHS 828) is the first candidate drug from a novel group of anti-tumour agents – the pyridyl cyanoguanidines, shown to be potent compounds interfering with cellular metabolism (inhibition of nicotinamide phosph...

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Autors principals: Lövborg, Henrik, Burman, Robert, Gullbo, Joachim
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709656/
https://ncbi.nlm.nih.gov/pubmed/19563661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-2-114
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