Selection of a trioxaquine as an antimalarial drug candidate

Trioxaquines are antimalarial agents based on hybrid structures with a dual mode of action. One of these molecules, PA1103/SAR116242, is highly active in vitro on several sensitive and resistant strains of Plasmodium falciparum at nanomolar concentrations (e.g., IC(50) value = 10 nM with FcM29, a ch...

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Detaylı Bibliyografya
Asıl Yazarlar: Coslédan, Frédéric, Fraisse, Laurent, Pellet, Alain, Guillou, François, Mordmüller, Benjamin, Kremsner, Peter G., Moreno, Alicia, Mazier, Dominique, Maffrand, Jean-Pierre, Meunier, Bernard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579890/
https://ncbi.nlm.nih.gov/pubmed/18987321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804338105
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