Pharmacokinetically guided phase I trial of topotecan and etoposide phosphate in recurrent ovarian cancer

A pharmacokinetically guided phase I study of topotecan and etoposide phosphate was conducted in recurrent ovarian cancer. The scheduling of the topoisomerase I and II inhibitors was determined using in vitro activity data. All patients had recurrent disease following prior platinum-containing chemo...

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Detalhes bibliográficos
Main Authors: Levitt, N C, Propper, D J, Madhusudan, S, Braybrooke, J P, Echeta, C, te Poele, R, Davies, S L, Flanagan, E, Hickson, I D, Joel, S, Ganesan, T S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361471/
https://ncbi.nlm.nih.gov/pubmed/15956976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602657
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