Phase I Study of Topotecan, Ifosfamide, and Etoposide (TIME) with Autologous Stem Cell Transplant in Refractory Cancer: Pharmacokinetic and Pharmacodynamic Correlates

PURPOSE: To determine the maximum tolerated dose (MTD) of topotecan in combination with ifosfamide, mesna, and etoposide (TIME), followed by autologous hematopoietic cell transplant (HCT), in patients with chemotherapy-refractory malignancies. EXPERIMENTAL DESIGN: Patients were treated with (in mg/m...

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Bibliografiska uppgifter
I publikationen:Clin Cancer Res
Huvudupphovsmän: Perkins, Janelle B., Goldstein, Steven C., Dawson, Jana L., Kim, Jongphil, Field, Teresa L., Partyka, James S., Fields, Karen K., Maddox, Beth L., Simonelli, Christine E., Neuger, Anthony M., Lush, Richard M., Sullivan, Daniel M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521635/
https://ncbi.nlm.nih.gov/pubmed/22028494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1540
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