Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition

The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90). Mutations in EGFR exons 18, 19, and 21 confer Hsp90 chaperone dependence. In non-small cell lung cancer (NSCLC), these mutations are associated with enhanced...

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Main Authors: Xu, W, Soga, S, Beebe, K, Lee, M-J, Kim, Y S, Trepel, J, Neckers, L
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360392/
https://ncbi.nlm.nih.gov/pubmed/17712310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603950
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