Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2

The benzoquinone ansamycin geldanamycin (GA) stimulates proteasome-mediated degradation of plasma membrane–associated ErbB2, a receptor tyrosine kinase. Drug sensitivity is mediated by ErbB2's kinase domain and occurs subsequent to the disruption of Hsp90 interaction with this domain. Full-leng...

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Autors principals: Xu, Wanping, Mimnaugh, Edward G., Kim, Jung-Sik, Trepel, Jane B., Neckers, Leonard M.
Format: Artigo
Idioma:Inglês
Publicat: Cell Stress Society International 2002
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC514806/
https://ncbi.nlm.nih.gov/pubmed/11892991
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