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Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2
The benzoquinone ansamycin geldanamycin (GA) stimulates proteasome-mediated degradation of plasma membrane–associated ErbB2, a receptor tyrosine kinase. Drug sensitivity is mediated by ErbB2's kinase domain and occurs subsequent to the disruption of Hsp90 interaction with this domain. Full-leng...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cell Stress Society International
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514806/ https://ncbi.nlm.nih.gov/pubmed/11892991 |
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