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EGFR exon 20 insertion mutations display sensitivity to Hsp90 inhibition in preclinical models and lung adenocarcinomas

PURPOSE: EGFR exon 20 insertions account for up to 10% of all EGFR mutations in lung adenocarcinomas, representing the third most common cluster of mutations. The management of advanced cancers with these mutations remains elusive, without an approved inhibitor. EXPERIMENTAL DESIGN: Preclinical mode...

詳細記述

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書誌詳細
出版年:Clin Cancer Res
主要な著者: Jorge, Susan E., Lucena-Araujo, Antonio R., Yasuda, Hiroyuki, Piotrowska, Zofia, Oxnard, Geoffrey R., Rangachari, Deepa, Huberman, Mark S., Sequist, Lecia V., Kobayashi, Susumu S., Costa, Daniel B.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295229/
https://ncbi.nlm.nih.gov/pubmed/30154228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1541
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