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Preclinical Characterization of Mobocertinib Highlights the Putative Therapeutic Window of This Novel EGFR Inhibitor to EGFR Exon 20 Insertion Mutations

INTRODUCTION: EGFR exon 20 insertion mutations account for 10% of all EGFR mutations and are mostly insensitive to approved EGFR tyrosine kinase inhibitors (EGFR TKIs). Novel EGFR TKIs have been developed or repurposed for these mutants. A limited number of preclinical studies have detailed these EG...

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Detaylı Bibliyografya
Yayımlandı:JTO Clin Res Rep
Asıl Yazarlar: Vasconcelos, Pedro E.N.S., Kobayashi, Ikei S., Kobayashi, Susumu S., Costa, Daniel B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959160/
https://ncbi.nlm.nih.gov/pubmed/33728415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtocrr.2020.100105
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